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Trichodysplasia spinulosa-associated polyomavirus : ウィキペディア英語版 | Trichodysplasia spinulosa-associated polyomavirus
Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a type of human polyomavirus. It is associated with trichodysplasia spinulosa, a rare skin disease only seen in immunocompromised patients. The virus was first described in July 2010. Trichodysplasia spinulosa is a proliferative skin disorder and had been long suspected to be associated with viral infection, particularly a polyomavirus infection, by electron microscopic studies. The Feltkamp laboratory at Leiden University Medical Center, the Netherlands, isolated this virus' DNA using rolling circle amplification. TSPyV is actually an extremely common component of human viral skin flora.〔http://wwwnc.cdc.gov/eid/article/17/8/11-0114_article.htm〕 Unlike Merkel cell carcinoma caused mostly by Merkel cell polyomavirus, trichodysplasia spinulosa is a dysplasia rather than a neoplasia and TSPyV appears to be actively replicating in the hair follicle inner root sheath cells. Thus, antiviral therapies currently available may have benefit in this disorder. TSPyV is the eighth human polyomavirus to be discovered. ==References==
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